N.C. Yeastract (Non-Conventional Yeast Search for Transcriptional Regulators And Consensus Tracking) is a curated repository of all known regulatory associations between transcription factors (TF) and target genes in non-conventional yeast species, with the exception of species of the genus Candida that have their own repository (http://pathoyeastract.org), based on hundreds of bibliographic references. It currently provides information for Zygosaccharomyces bailii, Kluyveromyces marxianus, Kluyveromyces lactis, Komagataella phaffii and Yarrowia lipolytica.

Facilities are also provided to enable the exploitation of the gathered data when solving a number of biological questions, as exemplified in the Tutorial. N.C. Yeastract allows the identification of documented or potential transcription regulators of a given gene and of documented or potential regulons for each transcription factor. It also renders possible the comparison between DNA motifs and the transcription factor binding sites described in the literature. Finally, the system provides a useful tool for grouping a list of genes (for instance a set of genes with similar expression profiles as revealed by microarray or RNA-seq analysis) based on their regulatory associations with known transcription factors. All analysis can be carried out based on the existing data for the non-conventional yeast species the user is working on or based on transcription associations occurring among orthologous genes and TFs in the remaining species in the database or, in Candida species and in the model yeast Saccharomyces cerevisiae, in association with PathoYeastract and Yeastract.

	Enter Zygosaccharomyces bailii		Enter Kluyveromyces lactis
	Enter Kluyveromyces marxianus		Enter Yarrowia lipolytica
	Enter Komagataella phaffii

P.T. Monteiro, J. Oliveira, P. Pais, M. Antunes†, M. Palma, M. Cavalheiro, M. Galocha, C.P. Godinho, L.C. Martins, N. Bourbon, M.N. Mota, R.A. Ribeiro, R.Viana, I. Sá-Correia, M.C. Teixeira (2020)
YEASTRACT+: a portal for cross-species comparative genomics of transcription regulation in yeasts
Nucleic Acids Research, 48(D1):D642-D649
doi:10.1093/nar/gkz859

C.P. Godinho, M. Palma, J. Oliveira, M. Mota, M. Antunes, M.C. Teixeira, P.T. Monteiro, I. Sá-Correia (2021)
The N.C.Yeastract and CommunityYeastract databases to study gene and genomic transcription regulation in non-conventional yeasts
FEMS Yeast Research, 21(6): foab045
doi:10.1093/femsyr/foab045

M.C. Teixeira, R. Viana, M. Palma, J. Oliveira, M. Galocha, M.N. Mota, D. Couceiro, M.G. Pereira, M. Antunes, I.V. Costa, P. Pais, C. Parada, C. Chaouiya, I. Sá-Correia, P.T. Monteiro (2023)
YEASTRACT+: a portal for the exploitation of global transcription regulation and metabolic model data in yeast biotechnology and pathogenesis
Nucleic Acids Research, advance access
doi:10.1093/nar/gkac1041